Cyclopentadecanone Properties

Softening point:63-65 °C (lit.)
Bubbling point:120 °C/0.3 mmHg (lit.)
Thickness 0.897 g/mL at 25 °C (lit.)
refractive file 1.4637 (gauge)
Streak point:120°C/0.3mm
capacity temp. Fixed in dry,Room Temperature
shading Colorless gem needles.
BRN 1618444
CAS DataBase Reference502-72-7(CAS DataBase Reference)
EWG’s Food Scores1
NIST Chemistry ReferenceCyclopentadecanone(502-72-7)
EPA Substance Registry SystemCyclopentadecanone (502-72-7

Cyclopentadecanone Chemical Properties,Uses,Production
Synthetic Properties
Synthetic Properties
Cyclopentadecanone is a musk aroma found in the fragrance organ of the male civet feline.
Various unions have been produced for its assembling [260]. Among these, the purported Story method is the main course that can possibly make cyclopentadecanone accessible for a bigger scope, yet because of the treatment of hydroperoxides, the interaction is hard to make due.
The interaction begins from tricyclohexylidene triperoxide, which is acquired by oxidation of cyclohexanone with hydrogen peroxide. Pyrolysis prompts a combination of 1,16-hexadecanolide and cyclopentadecane. The last option is oxidized by oxygen under boric corrosive catalysis to cyclopentadecanol, which is in this manner oxidized to cyclopentadecanone.
Because of the accessibility of since a long time ago binded aliphatic dicarboxylic acids by biotechnological processes, a Dieckmann buildup response may likewise perhaps be a valuable course to create this macrocyclic ketone.
Cyclopentadecanone is utilized in fine fragrances:
Answered to be found in the aroma organs of the Louisiana Cyclopentadecanone supplier muskrat Ondatra zibethicus rivalicius (Guenther, 1949).
Cyclopentadecanone is the super odoriferous part of musk.
By the cyclization of dinitriles in high weakening (Bedoukian. 1967).
Amalgamation Reference(s)
Science Letters, 7, p. 1283, 1978
The Journal of Organic Chemistry, 36, p. 3266, 1971 DOI: 10.1021/jo00821a003
Poisonousness assessment
Both the intense oral LD50 esteem in rodents and the intense dermal LD50 esteem in bunnies surpassed 5 g/kg (Moreno. 1975). The intense ip LD100 of cyclopentadecanone was not reached however was assessed to be >35mmol/kg for mice; an ip portion of 11-25 mmol/kg caused no passings in 24 hr and one of 8-92 mmol/kg caused no passings in 4 days (the length of the review). An oral portion of ≥45 mmol/kg caused no passings in mice. Serious unsettling joined by mental shock of the tail was brought about by low dosages of cyclopentadecanone; ridiculous assessment of the mice uncovered no particular pathology except for once in a while degenerative hepatitis, proximal rounded nephritis and, once in a blue moon, pancreatic putrefaction were observed after dosing with cycloalkanones (Caujolle and Caujolle, 1965).
Ketones are not promptly utilized, albeit the vast majority of them most likely go through appreciable decrease to the comparing optional alcohols, which are discharged in the pee as glucuronic corrosive forms (Williams, 1959). Cyclopentadecanone was hydroxylated in societies of four steroid-hydroxylating growths (Calonectria decora, Rhizopus nigricans, Daedalea rufescens and Ophiobolus herpotrichus), yet was not impacted by Aspergillus ochraceus. Starting assault happened at the most distant carbon iota, with yields of up to 26% of 8-hydroxycyclopentadecanone, in addition to dihydroxy mixtures and more polar items (Ashton, Bailey and Jones, 1974).
Cleansing Methods
Subliming Exaltone is superior to solidifying it from fluid EtOH for decontamination. The semicarbazone has m 186-187o. [Stevens and Erickson J Am Chem Soc 64 146 1942, Mathur et al. J Chem Soc 3505 1963, Biens and Hess Helv Chim Acta 71 1704 1988, Beilstein 7 III 203, 7 IV 118.]